(THC) content; industrial hemp is an agricultural crop for seed, fiber and hemp-derived CBD Oil. CBD oils derived from hemp typically contain only trace amounts of psychoactive THC (less than .3%). Historical Use of CBD (Cannabidial Oil) CBD oil found in the plant part (hemp) of the Cannabis Sativa plant has an effect on the endo-cannabinoid system in the brain, central and peripheral nervous system, fat, muscle tissue, and immune cells in humans. CBD interacts primarily with CB2 receptors with indirect actions on CB1 receptors and is thought to inhibit the release of glutamate, an excitatory neuro-transmitter and adenosine. 4 This is important because the inhibitory actions on the CB receptor play a role in maintaining normal brain activity and protecting the brain against seizures. 5,6 The CBD oil in this preliminary study was adminis-tered orally as gel-caps. There is some evidence that this dosage route can be inactivated somewhat by the stom-ach and liver before it can reach therapeutic levels in the patient's blood stream. Given the drawbacks of current methods of administration, oral dosage is the most compatible for dental phobic patients. In the future, improved formulations of CBD oil could improve the bioavailability of the medication. include a vitamin capsule in the same size and color as the CBD oil gel-cap to be used in a double blind study to eliminate the "placebo effect" of the medication. Neither the investigator nor the patient will have knowledge of the medication used in the study. The vial containing the medication will have a numerical code so that only the investigator at the company will know which code goes with which medication. CBD Oil Case Report & Pilot Study for Dental Patients of Jeffrey H. Ahlin, DDS ᕡ This preliminary case study is open to all patients in the practice but is limited to the first patients who signed up. ᕢ All medication for this study will be provided for the patient and come directly from Medici Quest Corporation in Colorado Springs, CO. ᕣ You must have a history of dental anxiety or dental phobia in order to enroll in this study. ᕤ Your blood pressure and pulse will be monitored before and after each dental visit. ᕥ You may end your participation in this study at any time by giving notice to the doctor or staff of the dental office. The Endocannabinoid System (ECS) In order to gain some understanding of how CBD oil helps the apprehensive or dental phobic patient, the mechanism of the ECS system has to be better explained. In the simplest terms, the ECS consists of compounds known as endocannabinoids as well as the receptors they bind with. These receptors and endo-cannabinoids are found in virtually every main organ in the human body and play a major role in sleep, mood, memory and even pain sensation. 7 This ECS system was discovered by Dr. Raphael Mechoulam, an organic chemist and professor of medicinal chemistry, at the Hebrew University of Jerusalem in Israel in 1992. 8 As the pathophysiologic role of the ECS system is further elucidated, much more accurate targeting for clinically successful treat-ments will be obtained. There is research being done 5,9 that indicates that Cannabidiol has particular benefits as a neuroprotectant. For example, Cannabidiol seems to limit neurologi-cal damage following stroke and trauma or in the treat-ment of neuro-degenerative disorders such as Alzheimer's disease and Parkinson's disease. The current case study, however, is attempting to understand the role of CBD oil in helping apprehensive dental patients obtain their necessary treatment. Questionnaire: ᕡ Has your dental anxiety or fear of dental proce-dures ever prevented you from seeking treatment? ____Yes ____No ᕢ Have you previously taken drugs of any kind before any dental procedure? ____Yes ____No Name of drug: _______________ ᕣ Have you ever had an unexpected or difficult reaction to any medication you have taken prior to any dental procedure? ____Yes ____No Please describe:_______________ ᕤ Please list your current medications on this form (use the back of the form if necessary). _______________________________________________ _______________________________________________ ᕥ Do you have any ongoing concerns about this study, your dental health, or your general medical condition? ____Yes ____No ᕦ Please sign the bottom of this form. Your signa-ture will acknowledge your consent to use the results of the study in a professional publication. Address any questions to the clinician or the clin-ical assistant. Thank you for your participation. Patient Questionnaire The following questionnaire and consent was obtained for each of the patients in the preliminary case study. For this particular study, the goal was to discern the patient's reaction to various dental procedures with and without taking CBD oil. An expanded study will Patient Historical Issues and Anecdotal Remarks Since the legalization of Cannabis Sativa for medical 40 Summer 2018 JAOS
Journal of the American Orthodontic Society Summer 2018/Buyer's Guide: Page 40
